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Enhancer Zeste 2 (EZH2) is a histone methyltransferase catalyzing histone H3K27me3 to mediate gene silence. It is implicated in governing various biological behaviors of human malignancies. In this review, we over-review EZH2 serves as an “on–off valve”—not only as a critical epigenetic repressor, but as a brand-new activator for specific downstream targets as well. Time and space it “switching on–off”...
Runt-related transcription factor 2 (RUNX2) is a member of the polyomavirus enhancer-binding protein 2/core-binding factor superfamily. RUNX2 is known for its contribution to osteoblast phenotype and bone formation. In recent years, increasing attention has been focused on the relationship of Runx2 with tumorigenesis. In different types of tumor cells, RUNX2 cooperates with its co-activators or co-inhibitors,...
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