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Enhancer Zeste 2 (EZH2) is a histone methyltransferase catalyzing histone H3K27me3 to mediate gene silence. It is implicated in governing various biological behaviors of human malignancies. In this review, we over-review EZH2 serves as an “on–off valve”—not only as a critical epigenetic repressor, but as a brand-new activator for specific downstream targets as well. Time and space it “switching on–off”...
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