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Apoptosis plays an important role in immune responses, but little is known about its involvement in contact hypersensitivity (CH). In this study, we have investigated the role of Fas/Fas ligand (FasL)-mediated apoptosis in the pathogenesis of CH. Mice were sensitized by one topical application of 100 μl of 3% oxazolone to shaved skin of the abdomen. Six days later, CH was provoked by challenging both...
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