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An oligonucleotide containing alternating anionic and stereo-uniform cationic dimethylaminopropyl-phosphoramidate linkages, d(T+T-) 7 T, is shown to bind with unusually high affinity to DNA [poly(dA) and d(C 2 A 15 C 2 )] and RNA [poly(rA)] targets in solutions of low ionic strength. The isomeric oligomer with the opposite configuration at the phosphoramidate...
The hybridization properties of the 5-methyl-isocytidine / isoguanosine base pair in synthetic oligodeoxynucleotides have been investigated. The 5-methyl-isocytidine / isoguanosine base pair has been determined to be isoenergetic with the cytidine / guanosine, and each base can effectively discriminate mismatches. The synthesis of oligodeoxynucleotides containing 5-methyl-2 -deoxyisocytidine was...
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