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Several ribonucleases (RNases) are known to exert a toxic effect on tumor cells, but the mechanism of their antitumor activity is still poorly understood. The review considers the RNase-cell component interaction that leads to induction of apoptosis in the tumor cell. The cell surface structures that potentially act as acceptors of exogenous RNases include acidic lipids, glycoproteins, heparan sulfate-containing...
The characteristics and the possible mechanisms of action of cytotoxic ribonucleases (RNases), promising antitumor drugs, are described. Original experimental data and the results of analysis of recent publications have made it possible to identify the cellular components providing for the selective effects of exogenous RNases on tumor cells, on the one hand, and to estimate the contributions of individual...
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