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BackgroundKeloids are marked by an overabundance of extracellular matrix. The antifibrotic effect of hepatocyte growth factor (HGF) is achieved by increasing the expression of matrix metalloproteinases (MMPs) that drive extracellular matrix catabolism. As such, we cultivated an RGD‐modified HGF‐expressing adenovirus (dE1‐RGD/lacZ/HGF) for introduction into keloid fibroblasts (KFs), looking at the...
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