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Heparin has been shown to be involved in the regulation of cellular Ca2+ by binding to many proteins with high affinity. Here we examined the effects of heparin on the plasma membrane Ca2+-ATPase from porcine brain synaptosome. Our results showed that heparin dramatically inhibited the ATP hydrolysis and Ca2+ uptake in the presence and absence of calmodulin. Together with controlled proteolysis by...
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