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New indocyanine green (IR820) is an indocyanine green analog which has attracted increasing attention in cancer phototherapy for the prominent absorbance at near‐infrared region and improved stability. However, the lack of tumor targeting ability is still an obstacle that severely limits the application of IR820. Lactobionic acid (LA) is a ligand for the asialoglycoprotein receptors which are overexpressed...
In this work, five Man‐DOX conjugates with different linkers were developed for targeted DOX delivery. The five Man‐DOX conjugates with different linkers were characterized by 1H NMR, HRMS, HPLC, UV–vis, and fluorescence spectroscopy. Man‐Suc‐DOX, Man‐TDG‐DOX, and Man‐DG‐DOX can self‐assemble into near‐spherical nanoparticles with hydrodynamic diameters of 150–200 nm and negative zeta potentials in...