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Surgery is the standard modality for the removal of tumors, either alone or in combination with other therapies such as radiotherapy and chemotherapy. These treatment adjuncts can be associated with significant toxicity, may not be appropriate at the time of diagnosis, and do not necessarily reduce the risk of metastasis. Consequently, a considerable volume of research has focused on the identification,...
Electrochemotherapy, utilizing bleomycin and cisplatin as chemotherapeutic drugs along with electric pulses locally delivered to the treated tumors, plays an important role in the local control of cancers. The treatment is easy to perform, on an outpatient basis, for the treatment of skin melanoma, breast cancer, or other tumor skin metastases. An objective response rate of 80% or more is reported...
Many patients with various types of cancers have already by the time of presentation, micrometastases in their tissues and are left after treatment in a minimal residual disease state [Am J Gastroenterol 95(12), 2000]. To prevent tumour recurrence these patients require a systemic based therapy, but current modalities are limited by toxicity or lack of efficacy. We have previously reported that immune...
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