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Background An extended-release formulation of amantadine (Osmolex ER™, Osmotica Pharmaceutical US LLC) was approved in February 2018 to treat Parkinson’s disease and drug-induced extrapyramidal reactions in adults. Objectives To determine the pharmacokinetic profile of extended-release amantadine in subjects with varying degrees of renal impairment. Methods Adults with normal renal function (creatinine...
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