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Although melittin, a water-soluble 26-amino acid peptide derived from bee venom of Apis mellifera , is known to exert anti-proliferative effects on various tumor cell lines, very little is known about its potential molecular mechanism(s) of action. In the present study, we investigated the effects of melittin on the AKT/mTOR/S6K1/4E-BP1 activation, associated gene products, cellular...
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