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Nowadays, conventional chemotherapy is commonly used in many cancers and support for other cancer therapies to improve the success rate of treatment. However, the conventional chemotherapy has many severe side effects. Thus, polymers and nanotechnology are applied to develop drug delivery systems and to increase the properties of anti-cancer drug including reduction of side effect. Many reports show...
Lamellarin N (Lam N) is a member of an interesting marine natural product class isolated from mollusks and subsequently found in ascidians and sponges. The limited aqueous solubility of Lam N hinders further studies on its cytotoxic activity against cancer cells. In this study, micelles comprising poly(ethylene glycol)-block-poly(ε-caprolactone) (PEG-b-PCL) and poly(ethylene glycol)-block-poly(D,...
One of the most useful techniques to treat cancer is chemotherapy. However, anticancer drugs, such as SN-38, have limited solubility with strong side effects. This work aims to use SN-38:β-cyclodextrin (β-CD) inclusion complex for an injectable polymeric in situ forming implant containing poly(ethylene glycol) (PEG), poly(ε-caprolactone), and poly(D, L-lactide). It was found that implant formation...
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