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Background
Basal forebrain cholinergic system (BFCS) dysfunction is associated with cognitive decline in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Apolipoprotein E (APOE) ε2 is a protective genetic factor in AD and MCI, and cholinergic sprouting depends on APOE.
Objective
We investigated the effect of the APOE ε2 allele on BFCS functional connectivity (FC) in cognitively normal...
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