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cNSCL1 encodes a bHLH transcription factor and is specifically expressed in the developing nervous system. We used a replication-competent retrovirus to drive misexpression of cNSCL1 in chick embryos. We found that cNSCL1 misexpression was embryonic lethal and the embryos exhibited gross abnormalities. Many skeletal bones were abnormal and some were completely absent. Expression of BMP4 was reduced...
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