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Key points
Low intrinsic aerobic capacity is associated with increased all‐cause and liver‐related mortality in humans.
Low intrinsic aerobic capacity in the low capacity runner (LCR) rat increases susceptibility to acute and chronic high‐fat/high‐sucrose diet‐induced steatosis, without observed increases in liver inflammation.
Addition of excess cholesterol to a high‐fat/high‐sucrose diet produced...
In this study, we sought to determine the temporal relationship between hepatic mitochondrial dysfunction, hepatic steatosis and insulin resistance, and to examine their potential role in the natural progression of non-alcoholic fatty liver disease (NAFLD) utilising a sedentary, hyperphagic, obese, Otsuka Long–Evans Tokushima Fatty (OLETF) rat model.OLETF rats and their non-hyperphagic control Long–Evans...
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