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Two new pairs of enantiomeric butenolides, (+)‐ and (−)‐suberiteslide A, (+)‐ and (−)‐subertieslide B had been obtained from the marine sponge Suberties sp. The structures with absolute configurations of these compounds were unequivocally determined by spectroscopic analyses and ECD (Electronic Circular Dichroism) method. It was the first separation of butenolides from the marine sponges of genus...