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In article number 1802618, Joong‐jae Lee, Hak‐Sung Kim, and co‐workers develop an intracellular protein delivery system by sequence specific DNA‐protein interactions for targeted therapy. Engineered nucleoproteins are sequentially assembled onto the surface of gold nanoparticles. The resulting nucleoprotein nanoparticles exhibit highly programmable designability for functional protein loading, and...
With a growing number of intracellular drug targets and the high efficacy of protein therapeutics, the targeted delivery of active proteins with negligible toxicity is a challenging issue in the field of precision medicine. Herein, a programed assembly of nucleoprotein nanoparticles (NNPs) using DNA and zinc fingers (ZnFs) for targeted protein delivery is presented. Two types of ZnFs with different...
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