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Clinical trial simulation (CTS) which is the process of simulating clinical trials based on a mathematical model can facilitate analyzing the ambiguity about the dose-response. To investigate how the drug effect varies with the parameters dose and Hill coefficient (N) this study simulates a pharmacokinetic-pharmacodynamic (PK-PD) model. Based on the MATLAB software the simulations illustrated the...
The aim of the study was to introduce the feasibility and utility of clinical trial simulation as applied to the clinical development of naratriptan. The probability of pain relief was estimated with the proportional odds model. The result was very close with the curve from the instruction. Clinical trial simulation resulted in a design with seven arms at 0, 1, 2.5, 5, 10, 15 and 20 mg. The curve...
In this paper, we presented a simulation based model to analysis the reliability of phased-mission system (PMS) with repairable components. Many researches on the repairable PMS supposed that failed components would be repairable only when the system is in a good state. It is different here that failed components can be repaired no matter what state is the system in. The mission successes if and only...
A global path planning method for complex mobile entity based on geometry algorithm in a strait environment was researched. Aiming at the complex mobile entity, the obstacles and the mobile entity were expressed as different polygons. Based on geometry algorithm, a set of folding linear path candidates were found out firstly. In order to enhance the success rate of path planning, the folding linear...
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