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Endogenous analogues of capsaicin, N-acyldopamines, were previously identified from striatal extracts, but the putative presynaptic role of their receptor, the TRPV 1 R (formerly: vanilloid or capsaicin receptor) in the caudate–putamen is unclear. We found that the endogenous TRPV 1 R agonists, N-arachidonoyldopamine (NADA) and oleoyldopamine (OLDA) with EC 50 values in the...
Although TRPV 1 vanilloid receptors (TRPV 1 Rs) have been assumed to be present in the brain, their role is not well-defined. Here, we tested the widely used TRPV 1 R agonists (E)-capsaicin (0.1–100μM) and resiniferatoxin (RTX, 0.1μM) on resting and K + -evoked Ca 2+ entry and radiolabelled GABA release in rat hippocampal nerve terminals. (E)-capsaicin and RTX...
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