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Early cognitive deficits in Alzheimer's disease (AD) seem to be correlated to dysregulation of glutamate receptors evoked by amyloid-beta (Aβ) peptide. Aβ interference with the activity of N-methyl-d-aspartate receptors (NMDARs) may be a relevant factor for Aβ-induced mitochondrial toxicity and neuronal dysfunction. To evaluate the role of mitochondria in NMDARs activation mediated by Aβ, we followed...
The effect of oxidative stress, induced by ascorbate (1.5 mM)/Fe 2+ (7.5 μM), on the cellular responses toN -methyl-d-aspartate (NMDA) receptor activation was evaluated by measuring the release of [ 3 H]GABA induced by NMDA from cultured retina cells. In retina cells submitted to oxidative stress the [ 3 H]GABA release evoked by NMDA, in a medium containing physiological...
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