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Gene regulation in sepsis is known to be controlled by the transcription factor NF-κB. However, the function of neuronal NF-κB in sepsis is not well defined. In a mouse model of sepsis induced by i.p. injection of lipopolysaccharides (LPS), we found an activation of NF-κB in the brain as shown by the induction of a transgenic NF-κB reporter. Inhibition of neuronal NF-κB by cell-specific expression...
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