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Objective: To investigate the effect of ER-a36 siRNA on the growth of ER-breast cancer cell. Methods: The inhibitive effects of ER-a36 siRNA with various concentration on ER negative breast cancer cell at 24 h and 48 h were determined with MTT, the changes in DNA quantity was detected by Annexin V-FITC/PI staining, the expression levels of ER-a36 and pro-caspase-3 by Western blot. Results: ER-a36...
Objective: To investigate the effect of IGF-IIP3 Deoxyribozymes (DRz) on the specificity of three kinds of carcinoma cell line. Methods: The inhibitive effects of DRz with various concentration on the growth of three cancer cells lines at different time were determined with MTT, the cell morphology under invert microscope and light microscope DAPI staining, changes in DNA quantity was detected by...
The functional knowledge of cancer proteins and cancer pathways is currently limited and not detailed enough, remaining as a major hurdle to cancer studies. Particularly, many cancer proteins are only annotated to high-level general GO categories. Here, we apply an efficient algorithm, by constructing function-specific protein-protein interaction sub-networks, to find finer functions of the cancer...
Thermal conductivities of biological tissue protein including normal protein and denatured protein were determined over the temperature range 0°C and 37°C using the tiny thermal probe method. The tiny thermal probe system had the advantages of high accuracy, a short test time, a low temperature rise and little water removal. The results showed that the thermal conductivities of the samples were found...
At first, this paper reviews the development of the protein secondary structure prediction. Some concerned secondary structure prediction methods are introduced. Then we propose a novel method to predict protein secondary structure , which substantially improves the prediction accuracy both over 80% in CB513 and RS126 database. At the end, we point out some possible trends in the protein secondary...
Selecting differentially expressed genes (DEGs) is one of the most important tasks in microarray applications. However, the sample sizes typically used in current cancer studies may only partially reflect the widely altered gene expressions in cancers. By analyzing three large cancer datasets, we show that, in each cancer, a wide range of functional modules are altered and have high disease classification...
In order to study mitochondria signal transduction pathway of apoptosis of SGC-7901 induced by n-butanol extract from Capparis spionosa L. (CSBE), effect of apoptosis of SGC-7901 induced by CSBE was observed. In addition, the changes of initiator, effector and marker in process of mitochondria signal transduction pathway were surveyed. The inhibitory and killing effects of SGC-7901 induced by CSBE...
Based on high-throughput data, numerous algorithms have been designed for finding functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors including the low a-priori probability of novel proteins participating in a detailed function and the lack of detailed functional knowledge for training algorithms. For such partially characterized...
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