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Many of the biopharmaceuticals currently produced are glycoproteins in which the oligosaccharide chains can impact markedly on bioactivity, antigenicity, pharmacokinetics, solubility, stability, and protease resistance. Glycosylation profile may vary based on the host system employed to produce a recombinant glycoprotein. Downstream and upstream processes employed to produce the finished product may...
This work reports the validation of a simple CZE method to be used in quality control of recombinant human glycosylated interleukin-7 (rhIL-7) batches produced in Chinese Hamster Ovary (CHO) cells. The separation buffer was a 25mM sodium borate at pH 10 containing 12mM diaminobutane (DAB) used as a dynamic coating agent of the capillary. This method allowed the separation of seven peaks ranging from...
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