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Cytotoxicity is a key function of natural killer (NK) and T cells; yet the molecular mechanism is unclear. We have biological, biochemical and molecular evidence to demonstrate that phosphatidyl- inositol (PI) 3-kinase is critical for direct NK lysis of tumor cells, via control of intracellular granule movement. Tumor cell engagement rapidly activated PI 3-kinase in NK cells within 5 min, as demonstrated...
IL-2, first identified as a T cell growth factor, has been proven to activate many cell types including polymorphonuclear neutrophils (PMN 3 )However, the mechanisms involved in PMN activation, especially the signaling pathways used by the IL-2R, are currently unknownHere we demonstrate that IL-2 has the ability to induce protein tyrosine kinases in human PMN, and we provide the first evidence...
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