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We have studied acute effects of the PPARγ agonist pioglitazone in vitro on human islets from both non-diabetic and type 2 diabetic subjects. In 5mM glucose, pioglitazone caused a transient increase in insulin secretion in non-diabetic, but not diabetic, islets. Continuous presence of the drug suppressed insulin release in both non-diabetic and diabetic islets. In islets from non-diabetic subjects,...
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