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NAD(P)H: quinone oxidoreductase 1 (NQO1) is an obligate two-electron reductase that is involved in chemoprotection and can also bioactivate certain antitumor quinones. Levels of NQO1 expression are elevated in tumors particularly in those of the lung, colon and breast in relation to the surrounding normal tissues. The high levels of NQO1 in solid tumors in combination with the ability to reduce many...
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