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Several studies have shown that neurons in the central and peripheral nervous systems express a variety of chemokine receptors (CKRs). Activation of these receptors can influence neuronal signaling by regulating synaptic transmission and neuronal excitability. This article presents electrophysiological methods that are currently used to study the normal and pathophysiological role for CKRs in the...
We investigated the modulation of voltage dependent Ca 2+ currents by chemokine receptors in heterologous expression systems and neurons. Fractalkine, SDF-1α<space>, RANTES and MDC inhibited the I Ba in CX3CR1-, CXCR4-, CCR5- and CCR4-expressing G1A1 cells, respectively. The I Ba inhibition was voltage-dependent, exhibited prepulse facilitation, and was...
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