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In this paper, we report a novel colorimetric strategy for the detection of small molecules by using Pb 2+ ion as an example. In this strategy, DNAzyme duplex modified gold nanoparticles (GNPs) are designed to be unable to interact with graphene oxide (GO). However, in the presence of Pb 2+ , the substrate strand of the DNAzyme is cleaved at its cleavage site, resulting in the disassembly...
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