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Diester phthalates are industrial chemicals used primarily as plasticizers to import flexibility to polyvinylchloride plastics. In this study, we examined the hydrolysis of di-n-butyl phthalate (DBP), butylbenzyl phthalate (BBzP) and di(2-ethylhexyl) phthalate (DEHP) in human liver microsomes. These diester phthalates were hydrolyzed to monoester phthalates (mono-n-butyl phthalate (MBP) from DBP,...
The effect of bisphenol A (BPA) on the kinetics of cytochrome P450 (P450)-dependent monooxygenases in rat liver microsomes was studied. Testosterone 16β-hydroxylase (TS16BH) and testosterone 2α-hydroxylase (TS2AH) activities were extensively inhibited by BPA at 100 μM (69% and 74%, respectively). The inhibition type was mixed for both P450-dependent monooxyganases. The K i of TS16BH and TS2AH...
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