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As a key regulator, telomerase plays important roles in aging and tissue renewal and lifespan. It has been demonstrated that telomerase reactivation in adult or old mice can lead to tissue regeneration, delayed aging and significant lifespan extension. Therefore, modulation of telomerase activity in a precise manner has been received much attention. Here we develop a strategy using near infrared (NIR)...
A novel drug-loaded pathogen-mimicking nanocomplex has been constructed for synergistic chemo-immunotherapy using detoxified lipopolysaccharide coated mesoporous silica nanoparticle. Detoxified lipopolysaccharide behaves as a dual-purpose entity that not only effectively mimics the function of the natural pathogen for triggering immune responses but also acts as a lid for inhibiting premature chemical...
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