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Cyclocreatine, an analog of creatine, is an efficient substrate for creatine kinase, but its phosphorylated form is a poor phosphate donor in comparison with creatine phosphate. Cyclocreatine was not very cytotoxic upon 24 h of exposure of human SW2 small-cell lung cancer cells to concentrations of up to 5 mM. However, combinations of cyclocreatine (0.5 mM, 24 h) with each of four antitumor alkylating...
The gastrointestinal tract is a rare site of metastatic spread. A case of lung cancer with gastrointestinal metastases was reported. This 36-year-old patient had a history of perforated peptic ulcer and was treated with a Billroth II subtotal gastrectomy 18 years ago. He was found to have a right upper lobe lung mass and received lobectomy in our hospital one month prior this admission. He was...
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