Wyniki wyszukiwania dla: Z. Liao

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Clinical Pharmacology Considerations on Recombinant Adeno‐Associated Virus–Based Gene Therapy

Kefeng Sun, Michael Z. Liao

The Journal of Clinical Pharmacology > 62 > S2 > S79 - S94

Recombinant adeno‐associated virus (AAV) is currently the most widely used platform for in vivo gene therapy. Clinical pharmacology is a central field for AAV gene therapy, represented by the pillars of pharmacokinetics, pharmacodynamics/efficacy, and safety. In this review, we provide a comprehensive summary of clinical pharmacology considerations for recombinant AAV. The main topics covered are...

artykuł

A hybrid design for dose‐finding oncology clinical trials

Jason J. Z. Liao, Feng Zhou, Heng Zhou, Lilli Petruzzelli, więcej

International Journal of Cancer > 151 > 9 > 1602 - 1610

Identifying the maximum tolerated dose (MTD) and recommending a Phase II dose for an investigational treatment is crucial in cancer drug development. A suboptimal dose often leads to a failed late‐stage trial, while an overly toxic dose causes harm to patients. There is a very rich literature on trial designs for dose‐finding oncology clinical trials. We propose a novel hybrid design that maximizes...

artykuł

VENETOCLAX‐OBINUTUZUMAB MODULATES CLONAL GROWTH: RESULTS OF A POPULATION‐BASED MINIMAL RESIDUAL DISEASE MODEL FROM THE RANDOMIZED CLL14 STUDY

O Al‐Sawaf, C Zhang, T Lu, M. Z Liao, więcej

Hematological Oncology > 39 > S2 > n/a - n/a

artykuł

Inferring latent heterogeneity using many feature variables supervised by survival outcome

Beilin Jia, Donglin Zeng, Jason J. Z. Liao, Guanghan F. Liu, więcej

Statistics in Medicine > 40 > 13 > 3181 - 3195

In cancer studies, it is important to understand disease heterogeneity among patients so that precision medicine can particularly target high‐risk patients at the right time. Many feature variables such as demographic variables and biomarkers, combined with a patient's survival outcome, can be used to infer such latent heterogeneity. In this work, we propose a mixture model to model each patient's...

artykuł

The safety and efficacy of open bedside tracheotomy: A retrospective analysis of 1000 patients

David Z. Liao, Vikas Mehta, Corin M. Kinkhabwala, Daniel Li, więcej

The Laryngoscope > 130 > 5 > 1263 - 1269

Objectives To evaluate the safety/efficacy of performing open bedside tracheotomy (OBT) in intensive care unit (ICU) patients and identify predictive factors for outcomes. Methods This is a retrospective cohort study. We identified 1000 consecutive patients undergoing OBT at a single university hospital starting from August 1, 2007. Complication rate, 30‐day mortality, decannulation rate, time...

artykuł

Systemic and local adipose tissue in knee osteoarthritis

J. Chang, Z. Liao, M. Lu, T. Meng, więcej

Osteoarthritis and Cartilage > 2018 > 26 > 7 > 864-871

Knee osteoarthritis (OA) is the most common joint disease. Body adipose tissue has been shown to be related to the development and progression of knee OA. Among systemic adipose tissues, subcutaneous adipose tissue is significantly and negatively associated with muscle mass and forces, and could be related to the presence and progression of knee OA. Visceral adipose tissue is associated with increased...

artykuł

Marijuana use differentially affects cannabinoid receptor expression in early gestational human endometrium and placenta

Naveen K. Neradugomma, Kaitlyn Drafton, Diana R. O'Day, Michael Z. Liao, więcej

Placenta > 2018 > 66 > C > 36-39

Marijuana is one of the most abused drugs among pregnant women leading to maternal and fetal abnormalities. Cannabinoids are the active ingredients of marijuana, which interact with cannabinoid receptors such as CNR1 and CNR2 to activate cellular signaling pathways. Human endometrium and placenta are known to express CNR1 and CNR2 and can respond to cannabinoid signaling. In this study, we show that...

artykuł

A novel method for assessing proximal tibiofibular joint on magnetic resonance images in patients with knee osteoarthritis

Z. Zhu, J. Chang, Z. Liao, M. Lu, więcej

Osteoarthritis and Cartilage > 2018 > 26 > S1 > S427-S428

artykuł

Short Fatigue Crack Behavior of LZ50 Axle Steel Under Rotating-Bending Cyclic Loading

B. Yang, S. Dai, Y. Y. Wu, Z. Liao, więcej

Strength of Materials > 2018 > 50 > 1 > 193-202

The short fatigue short crack replica tests using LZ50 axle steel hourglass-shaped specimens of were carried out under rotating-bending cyclic load. Seven sets of effective test data were obtained. The analysis demonstrated that short fatigue cracks generally originate in ferrite grains or on their boundaries, and then short cracks start propagating, which is strongly influenced by the microstructure...

artykuł

Diffusion Capacity of the Lungs Following Passive-Scattering Proton Therapy and Intensity-Modulated Photon Radiation Therapy for Locally Advanced Non–small Cell Lung Cancer

A. Elhammali, L.E. Colbert, R.U. Komaki, J.J. Lee, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E453-E454

artykuł

Toxicities and Clinical Outcomes of Concurrent Chemoradiation Therapy with 5-Fluorouracil Combined With Either Platinum or Taxanes for Localized Esophageal Cancer: A Propensity Score Matched Analysis

S.H. Lin, C. Xu, M. Xi, W. Deng, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E200

artykuł

Reduced Severe Toxicities in Elderly Esophageal Cancer Patients Treated with Intensity Modulated Radiation Therapy: A Population-Based Analysis

W. Deng, N. Zhang, H. Zhao, Y. Wang, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E143-E144

artykuł

The Proton Insurance Approval Process for Thoracic Patients: Metrics and Access

M.S. Ning, G.B. Gunn, M.B. Palmer, Q.N. Nguyen, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E407-E408

artykuł

Phase 1 Study of Pembrolizumab and Stereotactic or Hypofractionated Radiation for Metastatic Non–small Cell Lung Cancer

C. Tang, P. de Groot, K. Hess, S. Shabaan, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > S160-S161

artykuł

Pretreatment Circulating Tumor DNA for Risk Stratification of Locally Advanced Esophageal Cancer Treated With Chemoradiation and Surgery

T.D. Azad, A.A. Chaudhuri, A. Newman, H. Stehr, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > S90-S91

artykuł

Predicting the benefits of proton therapy in lung cancer patients from patient-specific anatomic and pathologic geometry

D.C. Hall, N. Shusharina, Z. Liao, R. Mohan, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E668

artykuł

Knowledge Engineering–Based Quality Evaluation of RTOG 1308 Proton Treatment plans

H. Geng, H. Zhong, T.G. Giaddui, Z. Liao, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E661-E662

artykuł

Comparative Effectiveness of Chemotherapy Alone Versus Chemotherapy and Radiation Therapy for Patients with Stage IV Esophageal Cancer

A.C. Moreno, N. Zhang, S. Giordano, R.U. Komaki, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E172-E173

artykuł

Reported Outcomes and Toxicities for Inoperable, Stage II-III Non–Small Cell Lung Cancer Patients Treated with Concurrent Chemotherapy and Intensity Modulated Proton Therapy

Q.N. Nguyen, P. Blanchard, R.U. Komaki, M.D. Jeter, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E484-E485

artykuł

Preliminary Results of a Multicenter, Randomized, Prospective Study Evaluating the Optimal Radiation Dose of Definitive Concurrent Chemoradiation for Inoperable Esophageal Squamous Cell Carcinoma

Y. Xu, X. Zheng, W. Zhu, W. Wang, więcej

International Journal of Radiation Oncology*Biology*Physics > 2017 > 99 > 2(S) > E200

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