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Oxidative catabolism of 1α,25-dihydroxyvitamin D 3 [1α,25(OH) 2 D 3 ] is mediated by either CYP24A1 or CYP3A4. In this paper, we tested whether induction of CYP3A4 in the LS180 intestinal cell model enhances clearance of 1α,25(OH) 2 D 3 and blunts its hormonal effect on expression of the apical membrane calcium transport protein, TRPV6. Treatment with the hPXR...
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