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The arterial microenvironment plays a vital role in the pathology of atherosclerosis (AS). However, the interplay between the arterial microenvironment and atherogenesis remains unclear, partially due to the gap between cell culture and animal experiments. Addressing this problem, the present study reports a microfluidic AS model reconstituting early‐stage AS. Physiological or AS‐prone hemodynamic...
On page 2022, a microfluidic atherosclerosis (AS) model reconstituting early‐stage AS is designed by X. Jiang and co‐workers. Physiological or AS‐prone hemodynamic conditions are recapitulated on the model. Under a hemodynamic background, AS‐prone biochemical factors such as hyperglycemia, hyperlipidemia, angiotensin‐II, tumor necrosis factor‐α (TNF‐α) and lipopolysaccharides lead to dysfunction of...
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