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Nineteen new derivatives based on the structure of marine natural product tasiamide B were designed, synthesized, and evaluated for their inhibitory activity against BACE1, a potential therapeutic target for Alzheimer’s disease. The hydrophobic substituents Val at P 3 position, Leu at P 1 ′ position, Ala at P 2 ′ position, and Phe at P 3 ′ position were found to significantly...
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