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Skp2 plays multiple roles in malignant tumours. Here, we revealed that Skp2 negatively regulates type‐I interferon (IFN‐I)‐mediated antiviral activity. We first noticed that Skp2 can promote virus infection in cells. Further studies demonstrated that Skp2 interacts with IFN‐I receptor 2 (IFNAR2) and promotes K48‐linked polyubiquitination of IFNAR2, which accelerates the degradation of IFNAR2 proteins...
Type I interferon (IFN‐I) is a common biological molecule used for the treatment of viral diseases. However, the clinical antiviral efficacy of IFN‐I needs to be greatly improved. In this study, IFN‐I receptor 2 (IFNAR2) was revealed to undergo degradation at the protein level in cells treated with IFN‐I for long periods of time. Further studies found a physical interaction between the E3 ubiquitin...
Interferon regulatory factor 3 (IRF3) is a critical transcription factor for inducing production of type I interferons (IFN‐I) and regulating host antiviral response. Although IRF3 activation during viral infection has been extensively studied, the inhibitory regulation of IRF3 remains largely unexplored. Here, we revealed that Midline‐1 (MID1) is a ubiquitin E3 ligase of IRF3 that plays essential...
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