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Tauroursodeoxycholic acid (TUDCA) has been used to treat many diseases effectively. TUDCA generation in vivo is a complex process involving five steps catalyzed by five enzymes in the enterohepatic circulation of bile salt. In this paper, we report a novel in vitro TUDCA preparation technology in which the epimerization of taurochenodeoxycholic acid (TCDCA) to TUDCA is directly catalyzed by immobilized...
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