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The charge burping model attributes the low defibrillation threshold (DFT) of the biphasic waveform to the removal of excess charge by the 2nd phase. This model predicts that the transmembrane potential change (Δ Vm) for the best biphasic waveforms is depolarization during the 1st phase followed by return of Vm during the 2nd phase back to its starting value just before the 1st phase. To test this...
We investigated the applicability of phase contrast magnetic resonance imaging (PC MRI) for direct measurement of effective orifice are (EOA) and explored the effect of flow rates, orifice sizes, and geometry on EAO and contraction coefficient (Cc) (which is the relationship of EOA to actual OA). On PC images, a 1.5T GE SIGNA system was used for imaging steady flows, ranging from 3.6-9.0 l/min.,...
Computer models suggest that hyperpolarizing defibrillation shocks (HPS) can reactive sodium channels, and that this may be a mechanism by which a shock can extend refractoriness. These studies, however, have not been tested in a biological model. Isolated chick ventricular myocytes (n = 8) were voltage clamped to quantitate whole cell inward Na + current. The voltage clamp protocol mimicked...
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