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In its classic description, the function of connexins is to form gap junctions. Although this description stands, recent studies show that connexin43 (Cx43) is not only a pore-forming gap junction protein. In fact, Cx43 is a part of a protein interacting network (the connexome), which likely regulates other functions in a gap junction–independent manner. Recently, it was reported that loss of the...
Brugada syndrome (BrS) is associated with loss of sodium channel function. Previous studies showed features consistent with sodium current (I Na ) deficit in patients carrying desmosomal mutations, diagnosed with arrhythmogenic cardiomyopathy ([AC]; or arrhythmogenic right ventricular cardiomyopathy [ARVC]). Experimental models showed correlation between loss of expression of desmosomal protein...
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