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Mutation of HNF-1β gene has been reported in early onset diabetes or MODY families and this gene has been defined as MODY5 gene. The aim of our study was to examine whether HNF-1β mutation contribute to early onset or multiple affected diabetes pedigrees in Chinese. Molecular scanning of HNF-1β gene promoter region, nine exons and flanking introns was performed in 154 unrelated probands from early...
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