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Tumor Immunotherapeutic Gels
In article number 2204273, Dunfang Zhang, Hang Zhao, and co‐workers demonstrate that an inosine‐based supramolecular hydrogel, IPBisoG, can achieve the gradual and sequential release of inosine and aPDL1. Inosine, which enhancs the proliferation and function of CD8+ T cells, together with aPDL1, the blocker of the immunosuppressive pathway in the tumor microenvironment,...
Inosine is proven to promote the proliferation and function of CD8+ cytotoxic lymphocytes (CD8+ T) under glucose restriction and enhance the efficacy of programmed cell death protein ligand‐1 (PD‐L1) blockade therapy. However, systemic administration of high frequencies and large doses of inosine and anti‐PD‐L1 antibody (aPDL1) is required, which inevitably reduces bioavailability and causes severe...
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