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Growth related oncogene protein-α (GRO-α) is a member of C-X-C chemokine and plays an important role in inflammatory responses. Expression of GRO gene family is regulated by a number of factors at both transcriptional and posttranscriptional levels. In the present study, we have addressed the possible regulation of GRO-α expression by ubiquitin-proteasome system. Cultures of human umbilical vein endothelial...
Growth-related oncogene protein-α (GRO-α) is a member of the C-X-C chemokine family with a wide variety of biological activities. We studied the production of GRO-α by human umbilical vein endothelial cells (HUVEC) in response to the stimulation with soluble form of interleukin-6 receptor α (sIL-6R). sIL-6R stimulated HUVEC to express GRO-α mRNA and secrete GRO-α protein in concentration-and time-dependent...
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