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Acute rejection (AR), initiated by alloreactive CD4 + T cells, hampers allograft survival. Soluble fibrinogen-like protein 2 (sFGL2) is a novel effector of CD4 + T cells. We previously found that serum sFGL2 significantly increased in renal allograft recipients with AR. In this study, sFGL2 secretion by CD4 + T cells and its mechanism were further explored both in vivo and...
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