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A new traceless soluble polymeric linker and a corresponding alkylating strategy has been developed. Dimethyl malonate was alkylated with a variety of polymeric halides and these resulting polymer bound malonates underwent further alkylation with additional monoalkyl halides. The methodology described should provide access to libraries of dialkyl malonates.
A traceless linker was developed on a soluble polymer support. The methodology allows for the facile attachment of molecules possessing an alkyl halide appendage. The coupled molecule can be further functionalized before subsequent cleavage via a two-step oxidation-reduction sequence. This sequence allows for the synthesis of molecules containing no trace of the linker and the formation of a new...
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