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Notch signaling plays an important role in the arteriogenesis. We hypothesized that the Notch inhibitor—γ-secretase inhibitor (GSI1) exerted its effects on the vasospasm via regulation of NF-κB and MMP-9. In this study, 160 male Sprague–Dawley (SD) rats were randomly assigned into four groups: Sham, subarachnoid hemorrhage (SAH), SAH treated with dimethyl sulfoxide (DMSO) and SAH treated with GSI1...
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