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Background The Cancer Atlas project has shown that p53 is the only commonly (96 %) mutated gene found in high-grade serous epithelial ovarian cancer, the major histological subtype. Another general genetic change is extensive aneuploidy caused by chromosomal numerical instability, which is thought to promote malignant transformation. Conventionally, aneuploidy is thought to be the result of mitotic...
We found by electron microscopy that the inter‐membrane space of embryonic stem cells is irregular and generally wider than in differentiated cells. Among a panel of nuclear envelope structural proteins examined, the expression of Syne1/nesprin‐1 was found to be greatly induced upon differentiation. Down‐regulation of Syne1 by siRNA in differentiated embryonic stem cells caused the nuclear envelope...
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