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Tetracycline analogues (oxytetracycline, doxycycline, and tetracycline) can inactivate copper, zinc superoxide dismutase (CuZnSOD). The interactions between tetracycline analogues and CuZnSOD were studied by using the UV–visible absorption and spectrofluorimetric method. Tetracycline analogues can cause fluorescence quenching of CuZnSOD by a static mechanism. The absorption spectrum and quenching...
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