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Phosphoinositides in general and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2 or PIP2) in particular have been recently found to function as important regulators of ion channels. Yet, while specific residues have been identified that affect channel–PIP2 interactions, the precise binding site of PIP2 has not been determined in any case. In addition to binding ion channels, however, phosphoinositides...
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