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The use of high dose of methotrexate (HDM), has been suggested as a mean of obtaining potentially cytotoxic cerebrospinal fluid (CSF) drug levels. The present study describes the pharmacokinetics in plasma and CSF for at least 65 hours after administratrion of HDM, and allows the simultaneous interpretation of the CSF and plasma available data. Methotrexate (MTX) concentrations in plasma and CSF were...
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