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Previous studies in our lab have shown a robust decrease in the rewarding properties of morphine in CREB αΔ mutant mice. To determine whether the genetic effects of the global CREB αΔ mutation are specific to reward or generalizable, we examined a variety of morphine-induced behaviors regulated by different neural circuitry. At low doses of morphine (5 and 10 mg/kg), CREB αΔ ...
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